Overview
- Researchers at the CSIR‑Centre for Cellular and Molecular Biology reported in Cell Reports that viral RNA can fold into G‑quadruplex shapes (rG4s) that bind alpha‑synuclein and promote the protein’s aggregation in infected cells.
- The team found that DDX39A, an RNA helicase normally in the nucleus, moves into the cytoplasm during infection and can unwind viral rG4s, reducing both viral replication and the rate of alpha‑synuclein amyloid formation.
- The finding was published Sept. 29 and is based on laboratory cell‑infection models, so the authors stress it shows a plausible molecular pathway rather than proof that routine infections cause Parkinson’s in people.
- The researchers say the cellular outcome depends on a balance between protective responses like DDX39A activity and processes that favor aggregation, and they are testing whether repeated or chronic infections could let harmful changes build up over years.
- If validated in animals and human studies, the pathway points to possible interventions targeting viral RNA structures or protein‑homeostasis mechanisms and underscores the need for long‑term cohort and mechanistic follow‑up.