Overview
- Williams lost to No. 13 Karolina Muchova 3–6, 6–2, 1–6 in Arthur Ashe Stadium.
- The crowd gave her standing ovations during her 25th appearance at the tournament.
- She is the oldest singles entrant at the US Open since Renee Richards in 1981, according to the sport’s federation.
- Williams returned to the tour in July after disclosing uterine surgery and years of misdiagnosis, earning singles wins in Washington.
- She entered on wildcards, including mixed doubles with Reilly Opelka, and Muchova closed the match in two hours on her first match point.