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Valneva Pulls U.S. Filings for Chikungunya Vaccine as FDA Halts Trials Over Safety Review

The decision follows FDA scrutiny of a foreign serious adverse event potentially linked to Ixchiq, with causality still undetermined.

The logo of French-Austrian biotech firm Valneva is seen outside their headquarters in Vienna, Austria, December 16, 2021. REUTERS/Lisi Niesner/File Photo

Overview

  • Valneva withdrew its U.S. biologics license application and Investigational New Drug filing for Ixchiq after the FDA suspended the vaccine’s license in August 2025.
  • The FDA placed the Ixchiq IND on clinical hold pending an investigation into a newly reported serious adverse event that occurred outside the United States.
  • Valneva says the case involved a younger adult who received three vaccines concurrently, including Ixchiq, and the report was submitted to VAERS and other pharmacovigilance systems.
  • The company states the event may be plausibly related to vaccination but causality has not been determined, and it is seeking more information to further characterize the case.
  • Valneva reports no studies are currently vaccinating participants, plans to pursue post‑marketing clinical activities pending regulatory discussions, and is engaging authorities in regions where the vaccine is licensed.