Overview
- University of Virginia clinicians reported the case in the Journal of Allergy and Clinical Immunology: In Practice as the first confirmed fatality from alpha-gal syndrome.
- A 47-year-old New Jersey airline pilot fell ill hours after a steak on a camping trip in 2024 and died two weeks later after a hamburger, with his autopsy initially labeled “sudden unexplained death.”
- Postmortem blood testing detected very high alpha-gal–specific IgE and elevated tryptase, findings that researchers say match a fatal allergic reaction.
- The man’s wife recalled a dozen itchy summer “chigger” bites, which investigators say were likely Lone Star tick larvae that can induce sensitization; alcohol, recent exercise, and ragweed exposure may have intensified the reaction.
- Experts urge clinicians to treat severe abdominal pain 3–5 hours after eating beef, pork, or lamb as possible anaphylaxis and call for broader tick-bite prevention and awareness as exposure risks grow.