Overview

• The study, published in *iMeta*, is the first to compare chimeric RNA profiles in prostate cancer across ethnic groups, focusing on Chinese and Western patients.
• Researchers validated over 100 chimeric RNAs, the largest catalog to date, with several showing strong diagnostic and prognostic potential.
• Distinct RNA patterns in Chinese patients were linked to tumor behavior and interactions with the microenvironment, highlighting opportunities for tailored therapies.
• Asian populations face higher prostate cancer mortality rates, with late-stage diagnoses contributing to a five-year survival rate below 30%.
• The findings underscore the need for expanded multiethnic research and suggest broader applications across diverse cancer types.