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Uterine Fibroids Linked to 81% Higher Long-Term Heart Disease Risk, Major U.S. Study Finds

Researchers urge heart-health discussions for patients with fibroids pending replication before guideline changes.

Overview

  • Analysis of 2.7 million commercially insured women found 450,177 with fibroids had higher risks of coronary, cerebrovascular and peripheral artery disease up to a decade after diagnosis.
  • Absolute 10-year event rates were about 5.4% for those with fibroids versus 3.0% for matched controls.
  • Women younger than 40 showed the strongest association, facing roughly a 3.5-fold higher risk over 10 years.
  • Elevated risk was observed across white, Black, Hispanic and Asian groups, according to the Journal of the American Heart Association report.
  • Authors noted the observational design, potential underdiagnosis of fibroids in controls and limited generalizability to privately insured populations, as American Heart Association experts emphasized preventive conversations.