Overview
- Researchers analyzed more than 3,800 participants aged 70 and older from the U.S. Health and Retirement Study.
- Vaccinated individuals showed lower inflammation along with slower epigenetic and transcriptomic aging and lower composite biological aging scores.
- Associations were observed even among participants vaccinated four or more years before blood sampling.
- The study is observational and may be influenced by confounding, including the healthy-user effect, so it cannot establish cause and effect.
- The findings, published in The Journals of Gerontology, Series A, complement prior reviews linking shingles vaccination to lower dementia risk.