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U.S. Whooping Cough Cases Top 25,000 in 2025 as Kentucky Confirms Third Infant Death

Declining coverage alongside waning immunity is driving outbreaks with the greatest toll on infants.

Overview

  • CDC data place this year’s pertussis count well above 2019’s 18,600, marking a second straight elevated year and the highest levels since roughly 2014.
  • Kentucky reports 566 cases as of Nov. 19 and three infant deaths within 12 months, the state’s first whooping cough fatalities since 2018.
  • State officials said none of the infants who died—or their mothers—had received pertussis vaccination.
  • Health authorities cite reduced vaccine uptake, shorter-lived protection from acellular vaccines, expanded PCR detection, and slower public-health tracking as key factors in the surge.
  • Officials urge on-time DTaP for children and Tdap during each pregnancy, early testing and treatment, and continued surveillance for emerging macrolide antibiotic resistance.