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U.S.-Iran Nuclear Talks Reach Fifth Round as Enrichment Dispute Intensifies

Negotiations in Rome mediated by Oman focus on Iran's enrichment rights and U.S. sanctions relief, while regional tensions escalate over potential Israeli strikes.

Iranians pass by a mural that depicts the two Supreme Leaders of Iran near Enghelab (Revolution) Square in downtown Tehran, Iran on April 8, 2025, four days before the first round of indirect nuclear negotiations with President Trump's administration hosted and mediated by Oman.
This satellite photo from Planet Labs PBC shows the Bushehr nuclear reactor in Iran on May 1.
In this Jan. 5, 2018 file photo, Iranian senior cleric Ahmad Khatami delivers his sermon during Friday prayer ceremony in Tehran, Iran. In recent months, Iran has been beset by economic problems despite the promises surrounding the 2015 nuclear deal it struck with world powers.
Iranian Foreign Minister Abbas Araghchi attends a press conference with his Syrian and Iraqi counterparts (not pictured), after a trilateral meeting in Baghdad, on December 6, 2024. Fuad Hussein said his country must guard against attack, as Islamist-led rebels pressed a shock offensive in neighbouring Syria. (Photo by AHMAD AL-RUBAYE / AFP) (Photo by AHMAD AL-RUBAYE/AFP via Getty Images)

Overview

  • The fifth round of indirect nuclear negotiations between the U.S. and Iran is underway in Rome, with uranium enrichment remaining the primary sticking point.
  • The U.S. demands a complete halt to Iran’s uranium enrichment, while Iran insists it will not agree to any deal that limits its domestic enrichment capabilities.
  • Iranian Foreign Minister Abbas Araghchi has warned of 'special measures' to defend nuclear facilities against Israeli threats, further escalating regional tensions.
  • U.S. intelligence reports suggest Israel is preparing for potential strikes on Iran’s nuclear sites, raising concerns about the risk of military escalation.
  • Oman continues to mediate the talks, with both sides under pressure to reach an agreement as Iran’s economy struggles under U.S. sanctions and international scrutiny grows over its enriched uranium stockpile.