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U.S. and Iran Prepare for Critical Round of Nuclear Talks as Tensions Escalate

With a two-month deadline looming, diplomatic efforts face internal U.S. divisions, Israeli opposition, and Iranian security warnings.

Iran's Foreign Minister Abbas Araqchi attends a press conference following a meeting with Russia's Foreign Minister Sergei Lavrov in Moscow, Russia, April 18, 2025. Tatyana Makeyeva/Pool via REUTERS/File Photo
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U.S. Secretary of State Marco Rubio looks on upon his arrival at the Quai d'Orsay, France's Ministry of Foreign Affairs, before a bilateral meeting with his French counterpart in Paris, France April 17, 2025. JULIEN DE ROSA/Pool via REUTERS/File Photo
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Overview

  • A third round of indirect nuclear negotiations between the U.S. and Iran is set to begin this weekend in Rome, following two earlier rounds in Oman and Rome.
  • Internal divisions within the Trump administration persist, with factions debating whether to allow limited uranium enrichment or demand total dismantlement of Iran's nuclear program.
  • IAEA Director General Rafael Grossi has called on Iran to clarify new tunnel construction at the Natanz nuclear site and announced the dispatch of a technical team to Tehran for further verification talks.
  • Israeli Prime Minister Benjamin Netanyahu and U.S. Senator John Fetterman have both urged President Trump to abandon diplomacy, with Fetterman advocating for military strikes on Iran's nuclear facilities.
  • Iranian officials have accused Israel and allied groups of attempting to sabotage the negotiations and stated that their security forces are on high alert to counter potential threats.