Overview
- Published on November 18 in Cell Stem Cell, the study details a three-dimensional bone marrow construct composed entirely of human cells.
- The system is built on a hydroxyapatite bone scaffold seeded with reprogrammed pluripotent stem cells that are directed to form diverse marrow cell types.
- Analyses show the model closely matches the human endosteal niche and maintains hematopoiesis in vitro for weeks.
- The construct measures roughly 8 millimeters in diameter and 4 millimeters in thickness, exceeding the size of prior in vitro marrow systems and offering a potential complement to some animal studies.
- The team highlights prospects for drug screening and patient-tailored models, noting that miniaturization and further validation are necessary for high-throughput or clinical use.