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24m ago

Underdog Wave Resets NFL Betting Landscape as Eagles–Giants Opens Week 6

Sportsbooks reported a winning Week 5 after heavy favorites like the Rams, Cardinals and Bills were toppled.

Will Bijan Robinson and the Atlanta Falcons beat the Buffalo Bills on Monday Night Football? NFL Week 6 predictions, picks, odds preview the game on Oct. 13, 2025.
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Will Baker Mayfield and the Tampa Bay Buccaneers beat the San Francisco 49ers? NFL Week 6 predictions, picks, odds preview the game on Oct. 12, 2025.
Sep 28, 2025; Arlington, Texas, USA; Green Bay Packers defensive end Micah Parsons (1) leaves the field after the game ended in a tie at AT&T Stadium. Mandatory Credit: Jerome Miron-Imagn Images

Overview

  • Book operators said public moneyline parlays unraveled, with South Point’s Chris Andrews and The SuperBook’s Casey Degnon describing the underdog results as locking in a profitable day.
  • The 49ers stunned the Rams in overtime without Brock Purdy, the Patriots beat the Bills on a late Drake Maye drive capped by a 52-yard Andy Borregales kick, and Tennessee edged Arizona after Emari Demercado’s goal-line fumble; CBS noted six double-digit comebacks tied an all-time weekly high.
  • Week 6 starts Thursday at MetLife Stadium with Jaxson Dart making his prime-time debut for the Giants against an Eagles team that has won 10 of its past 11 Thursday games, while New York has dropped 10 straight on Thursdays.
  • Philadelphia listed Saquon Barkley as a limited participant on the estimated report and defensive tackle Jalen Carter as questionable with a heel injury, while All-Pro guard Landon Dickerson was ruled out.
  • Analysts highlighted continued volatility for bettors, pointing to uncertainty around the 49ers’ Week 6 availability as they visit the Buccaneers, rising MVP odds for Baker Mayfield, and underdog interest in matchups such as Lions at Chiefs.