Overview

• San Francisco listed Brock Purdy (toe/shoulder) and Mac Jones (knee) as limited Wednesday, while receivers Ricky Pearsall, Jauan Jennings and Jordan Watkins did not practice.
• Pearsall described his knee issue as soreness and said he expects to play, and defensive tackle C.J. West had thumb surgery with hopes of returning in a cast if he practices later this week.
• Head coach Kyle Shanahan said Purdy is progressing without clarifying Week 4 availability, and third-stringer Adrian Martinez received an expanded share of practice reps.
• Star edge rusher Nick Bosa is reported out for the season with a torn ACL, putting more on rookie Mykel Williams and veteran Bryce Huff as the 49ers’ defense continues to rank top-five in points and yards allowed.
• Jacksonville enters 2-1 with a defense top-10 by yardage and tied fifth in scoring, features rookie Travis Hunter in a two-way role, and faces a 49ers team favored by 3.5 points with a 46.5 total.