Overview

• Kickoff is 8:20 p.m. ET at Highmark Stadium, with Buffalo seeking a 5-0 start after a 31-19 win over the Saints and New England entering 2-2 following a 42-13 victory over the Panthers.
• Sportsbooks list the Bills as 8.5-point favorites with a 49.5 total and moneyline around Buffalo -424 and New England +328.
• SportsLine’s 10,000-simulation model is leaning over the total and indicates one side of the spread hits in nearly 70% of simulations.
• Buffalo averages 404 yards and 33.3 points per game with 163.5 rushing yards, facing a Patriots defense allowing just 77.5 rushing yards per game.
• NBC carries the primetime telecast with streaming on Peacock and Fubo, and published previews largely favor Buffalo, including a 33-27 prediction.