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Unbeaten Bills Host Patriots as Big Favorites on Sunday Night Football

Oddsmakers plus models favor Buffalo, with the league’s top rushing attack set to test New England’s elite run defense.

How to watch the Buffalo Bills face the New England Patriots on Sunday Night Football on the NFL Week 5 schedule today, with TV channel, time, streaming information for the Oct. 5, 2025 game.
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Josh Allen is setting himself up to possibly win MVP for a second straight season.

Overview

  • Kickoff is 8:20 p.m. ET at Highmark Stadium, with national coverage on NBC and streams available on Peacock and Fubo.
  • Buffalo enters 4-0 against 2-2 New England, with the Bills laying about 8.5 points and a total near 49.5; moneyline pricing heavily favors Buffalo.
  • The Bills average roughly 404 yards and 33.3 points per game, powered by a 163.5-yard rushing attack, while the Patriots allow only about 77.5 rushing yards per game.
  • Storylines include Josh Allen’s MVP-caliber start, James Cook’s prolific rushing, Drake Maye’s rising efficiency on key downs, and Stefon Diggs’ first game back in Buffalo as a Patriot.
  • Projection models lean to the over and show one side of the spread hitting in nearly 70% of simulations, reflecting broad analytical confidence in Buffalo.