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UNAM Pilot Finds Magnetic Brain Stimulation Cuts Alcohol Cravings by 80%

Researchers targeted accelerator-brake circuits in the brain to harness TMS’s potential for addiction therapy

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Overview

  • In a 48-participant pilot, repetitive TMS reduced alcohol cravings by nearly 80% within two weeks, with only one relapse reported
  • Sessions were combined with psychological support and pharmacotherapy to reinforce prefrontal inhibitory control and dampen subcortical craving signals
  • The approach is based on a neurobiological model that distinguishes an overactive “accelerator” in the amygdala from a weakened “brake” in prefrontal regions
  • High-end TMS devices cost between 700,000 and 2 million pesos, posing economic barriers to broader clinical adoption in Mexico
  • Lack of formal health-system regulations risks limiting access and encouraging the proliferation of unverified stimulators