Overview

• The study screened 74 inflammation-related proteins in blood samples from more than 2,000 women in the TwinsUK cohort to assess links with frailty and area-level deprivation.
• Ten proteins were identified as markers of both social disadvantage and frailty, with four—TNFSF14, HGF, CDCP1 and CCL11—also tied to higher cardiovascular risk.
• CDCP1 stood out as a predictor of future heart events, including narrowed or blocked arteries, pointing to its value as an early warning biomarker.
• An independent cohort of women from the Nottingham Osteoarthritis Study confirmed the proteomic associations across populations.
• Researchers are investigating gut microbiome interactions and devising dual medical and social policy interventions to mitigate heart-disease risk in underserved communities.