Overview

• At IASLC WCLC 2025, researchers reported outcomes from 574 screen-detected lung cancer cases in the Yorkshire Lung Screening Trial and the North & East Manchester Lung Health Check.
• Of these cases, 190 involved patients aged 75–80, and their stage distribution matched that of patients aged 55–74.
• Curative-intent treatment was delivered in 87% of cases overall, with surgical resection less common in the older group (42% vs 58%, p<0.001).
• All-cause mortality was higher among patients aged 75–80 (hazard ratio 1.54), with four-year mortality of 44% compared with 34% in those aged 55–74.
• Among patients who underwent surgery, four-year mortality was similar between age groups (16% in 75–80 vs 18% in 55–74; HR 1.00), supporting selection based on surgical fitness rather than age alone.