Overview

• Study published in Science Advances analyzed over 1,500 biopsies from more than 1,300 women to pinpoint abnormal decidual reactions as a key factor in miscarriage recurrence.
• The diagnostic measures molecular signals of the womb lining’s decidual reaction and is being piloted at Tommy’s National Centre for Miscarriage Research.
• Pilot programme has supported over 1,000 women, many of whom received targeted therapies and subsequently carried healthy pregnancies.
• Researchers discovered that dysfunctional decidual responses recur across menstrual cycles, revealing a consistent and preventable cause of early pregnancy loss.
• Findings shift the focus from embryo quality to endometrial health and lay groundwork for treatments aimed at reducing miscarriage rates.