Overview

• Newcastle University scientists used pronuclear transfer to perform mitochondrial replacement IVF, resulting in eight healthy infants.
• Detailed genetic analyses showed the babies had undetectable or clinically negligible levels of mutant mitochondrial DNA.
• Each case received individual approval from the UK’s Human Fertilisation and Embryology Authority under 2015 legislation.
• The technique remains banned in the United States but is permitted for clinical use in Australia.
• Lawmakers have proposed raising the minimum donor age and curbing clinic advertising in response to emerging ethical concerns over egg-donor welfare.