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10h ago

UK Probes Safety of Three-Parent IVF After Eight Births and Mitochondrial Reversions

Regulators in the UK are probing long-term safety after studies found low-level reversion in donor mitochondria.

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Overview

  • Eight children born through mitochondrial replacement therapy in the UK show no signs of inherited mitochondrial disease to date.
  • New England Journal of Medicine data reveal reversion mutations of up to 16 percent in some treated embryos without immediate health effects.
  • Only eight of 22 embryos generated via the procedure resulted in live births, indicating a success rate near 36 percent.
  • The Human Fertilisation and Embryology Authority has imposed extended follow-up studies to assess potential long-term risks of germline mitochondrial modification.
  • India’s ICMR and Department of Biotechnology are reviewing ethical and regulatory frameworks for mitochondrial donation as international interest mounts.