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UK Launches £42m Transform Trial to Compare Prostate Cancer Screening Options

Findings are intended to guide UK screening recommendations.

Overview

  • First invitations have gone out and initial testing has begun at the InHealth community diagnostic centre in Ealing.
  • Stage one will recruit 16,000 men aged 50–74, or 45–74 for higher‑risk groups, with participants invited directly by their GPs rather than volunteering.
  • The study will benchmark PSA blood tests, genetic risk testing and rapid MRI scans against current NHS diagnostic pathways.
  • Funding totals £42 million, with £16 million from the NIHR and the remainder from Prostate Cancer UK and its partners, and the trial will build a large bank of samples, images and data for future research.
  • Approaches that perform best will be tested in up to 300,000 men in a subsequent phase, with at least one in ten invitations to Black men, as the National Screening Committee considers a prostate screening recommendation that reporting suggests may focus on high‑risk groups.