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UK Experts Warn of Dangerous Mixes of Common Prescription and Over-the-Counter Medicines

Low side-effect awareness among over-65s leaves many vulnerable to harmful drug combinations.

Overview

  • Only 41% of patients said they were definitely told about side effects, 30% said they were not told, and nearly two million over-65s take seven or more prescribed medicines daily, according to the Nuffield Trust.
  • Heart drugs such as furosemide or indapamide can trigger sudden blood-pressure drops, increasing dizziness and fall risk in older people.
  • Taking metformin alongside diuretics like furosemide can heighten dehydration-related lactic acidosis risk, further undermining stability and safety.
  • Combining antihistamines with benzodiazepines can amplify drowsiness and confusion, while pairing SSRIs with decongestants may disrupt blood pressure, sleep and mood.
  • Experts urge monitoring for abrupt behavioural changes and arranging medication reviews, alongside simple home safety steps such as better lighting and non-slip mats.