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2h ago

UCLA Study Ties Inflammation to Specific Fatigue Types in Early Breast Cancer

The peer-reviewed analysis of 192 women tracked across 18 months found associations that persisted after clinical and demographic adjustment.

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Overview

  • Findings published October 6 in CANCER (DOI: 10.1002/cncr.70038) link inflammatory activity to distinct dimensions of cancer-related fatigue.
  • Higher TNF-α, sTNF-RII, and IL-6 were associated with greater general fatigue characterized by tiredness and exhaustion.
  • Physical fatigue correlated positively with TNF-α, sTNF-RII, and CRP, indicating a marker-specific relationship with bodily weakness and heaviness.
  • No significant associations were detected for cognitive fatigue, while TNF-α and sTNF-RII showed inverse relationships with emotional fatigue.
  • Associations were measured from pre-treatment through 18 months post-treatment and remained after adjusting for age, race, education, BMI, and cancer stage, reflecting observational links rather than proven causation.