Overview
- UC San Diego researchers published the GNPS Drug Library and a free online analysis app in Nature Communications on December 9, 2025.
- The reference compiles mass‑spectrometry fingerprints for 4,723 drugs plus nearly 100,000 documented breakdown elements to enable untargeted detection across sample types.
- Validation detected 75 distinct drugs in nearly 2,000 American Gut Project samples and showed regional and sex‑linked differences in exposure patterns.
- Disease and clinical cohorts showed expected medication signatures and co‑medications, with HIV analyses linking specific antivirals to shifts in gut‑derived molecules.
- Testing of more than 3,000 food products identified antibiotics in meat and a pesticide in vegetables, and the team plans to expand curation using large language models and generative AI.