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UC San Diego Engineers Bacteria to Mass-Produce Octopus Camouflage Pigment

The team tied cell survival to pigment synthesis using a growth‑coupled design optimized by automation.

Overview

  • The study reports xanthommatin titers of roughly 1–3 grams per liter, an increase of about 1,000 times over prior milligram‑level methods.
  • Engineered microbes produce the pigment together with formic acid that fuels growth, creating a self‑sustaining production loop.
  • Robotic high‑throughput evolution and machine learning identified beneficial mutations and enabled production directly from a single nutrient source.
  • The peer‑reviewed findings appear in Nature Biotechnology, with key contributions from Bradley Moore, Leah Bushin and Adam Feist.
  • Potential uses include cosmetics, UV protectants, photoelectronic devices, thermal coatings, color‑changing paints and environmental sensors, with interest reported from the U.S. Department of Defense and skincare companies.