Overview

• Researchers employed a GEVAL fluorescent sensor to map age-related declines in guanosine triphosphate in Alzheimer’s model neurons
• In vitro treatment with nicotinamide plus epigallocatechin gallate restored GTP to youthful concentrations within 24 hours
• Revived GTP levels triggered activation of Rab7 and Arl8b GTPases, enhanced autophagy and reduced amyloid beta aggregates and oxidative stress
• The peer-reviewed findings appeared August 2 in GeroScience, showcasing a nonpharmaceutical approach using dietary compounds
• Investigators are now tackling oral nicotinamide’s rapid bloodstream inactivation to develop clinically viable delivery methods