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Two Brain Regions Encode Facing Direction Anchored to a Global Axis

Researchers used a virtual reality taxi task with brain imaging in 15 people to capture naturalistic navigation.

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According to the researchers, these findings suggest that these brain regions may serve as a neural compass. Credit: Neuroscience News

Overview

  • Neuroimaging showed two brain regions consistently represented a person's forward-facing direction across different scenes, task phases, and locations in a virtual city.
  • The directional code referenced the environment's north–south axis, indicating a global frame of orientation rather than local visual cues.
  • Participants performed pickups and drop-offs in an immersive taxi-driving simulation while their brains were scanned.
  • The authors describe these signals as a neural compass that supports stable orientation during navigation.
  • The peer-reviewed study appears in the Journal of Neuroscience (DOI: 10.1523/JNEUROSCI.1765-24.2025), and the researchers say the signals could aid detection or monitoring of disorientation in neurodegenerative disease.