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Twice-Yearly HIV Prevention Shot Lenacapavir Starts Rollout in South Africa, Eswatini and Zambia

Access currently depends on a limited no‑profit pledge pending generic supply from 2027.

Overview

  • First doses were administered on World AIDS Day, with Zambia and Eswatini launching the injection at public ceremonies.
  • In South Africa, a Wits University research unit funded by Unitaid is overseeing early use, with a broader national rollout expected next year.
  • Gilead Sciences committed to provide the drug at no profit for two million people over three years in high HIV‑burden countries.
  • Unitaid and the Bill & Melinda Gates Foundation announced agreements enabling generics from 2027 at about $40 per year in more than 100 countries.
  • Critics say the current pledge will not meet need and note the US list price of about $28,000 per person per year as a barrier to equitable access.