Overview

• Researchers isolated and structurally characterized twelve distinct indole-functionalized compounds produced by Paracoccus sanguinis.
• Three lead metabolites significantly lowered reactive oxygen species in treated human skin cells.
• The same three compounds also suppressed inflammatory proteins and inhibited collagenase activity in vitro.
• Two of the top anti-aging candidates were newly identified in this study, highlighting unexplored microbial chemistry.
• The research team will next evaluate the safety, bioavailability and efficacy of these metabolites in human clinical studies.