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Tufts Develops Biodegradable Dental Implants That Aim to Restore Sensation

Researchers plan preclinical trials to verify whether new nerve growth around the implants can relay sensory signals to the brain

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Overview

  • The implants are wrapped in a biodegradable coating loaded with stem cells and a protein that encourages them to differentiate into nerve tissue
  • Tiny, memory-foam-like nanofibers in the coating expand after placement to fill the socket and allow a gentler, minimally invasive surgical approach
  • In rodent studies, implants remained securely in place for six weeks without signs of inflammation or rejection and showed soft-tissue integration instead of direct bone fusion
  • The next phase involves monitoring brain activity in larger animal models to confirm that the regenerated nerves can transmit pressure and texture information
  • Researchers believe the same coating and nerve-integration technique could be adapted for other bone implants, including hip replacements and fracture repairs