Overview

• President Trump said the FDA will notify physicians that acetaminophen use in pregnancy can be associated with increased autism risk and recommended restricting it to medically necessary cases.
• He highlighted leucovorin as a potential intervention for autism, as regulators cleared a formulation to treat rare cerebral folate deficiency without approving it as an autism treatment.
• The American College of Obstetricians and Gynecologists and other experts criticized the move as unsupported, noting acetaminophen remains the recommended analgesic in pregnancy and citing a 2024 Swedish JAMA study finding no causal link and a 2025 review reporting associations without proving causality.
• Tylenol maker Kenvue rejected any causal connection and said independent evidence shows none, and its shares fell about 7.5%, wiping roughly $2.6 billion in market value.
• Trump also questioned routine vaccination practices by suggesting spacing shots and delaying the hepatitis B vaccine for newborns, positions for which he offered no new data.