Overview

• Protein engineering anchored human thrombin to a bacterial cellulose matrix without harsh chemicals to create a hemostatic composite dressing
• In vitro coagulation assays confirmed superior clotting performance compared with conventional materials
• A rat liver incision model achieved effective hemostasis in under one minute using the thrombin-anchored dressing
• In a simulated deep second-degree burn model, treated wounds closed 40% faster than controls over a five-day period
• Comprehensive biosafety tests including cytotoxicity, hemolysis and histocompatibility analyses validated the dressing’s excellent biocompatibility and safety