Overview

• The study treated 22 women with pronuclear transfer and resulted in eight healthy live births free of mitochondrial disease
• Genetic analyses showed very low or undetectable levels of maternal mitochondrial mutations in all eight infants
• In a separate Greek trial using a different mitochondrial donation method, one child exhibited 30–60% carry-over of maternal mitochondria
• Australia’s planned clinical rollout remains unlicensed and Monash IVF is under investigation after two patients received incorrect embryos
• US federal regulations continue to bar heritable germ-line modifications like pronuclear transfer from clinical use