Overview
- San Francisco fell to 5-3 after Houston controlled the game from start to finish at NRG Stadium.
- Houston outgained the 49ers 475-223 and held the ball for 41:22 to 18:38, stifling Kyle Shanahan’s offense.
- C.J. Stroud threw for a season-high 318 yards and two touchdowns, while Mac Jones finished 19-of-32 for 193 yards with two scores and an interception.
- The 49ers lost defensive linemen Jordan Elliott and Sam Okuayinonu to ankle injuries and linebacker Dee Winters to a knee issue, with their return timelines still unclear.
- Deommodore Lenoir intercepted Stroud to end San Francisco’s long drought without a pick, and tight ends George Kittle and Jake Tonges each caught touchdown passes.