Overview

• The peer-reviewed study by Huu Tuan Nguyen and colleagues was published on August 14, 2025, in Biofabrication (DOI: 10.1088/1758-5090/adfbc3).
• The device integrates a tumor spheroid with capillary-like, perfusable vessels whose inflow can be occluded by delivered agents to simulate hepatic artery embolization.
• Efficacy metrics include tumor cell death, vessel regression, cytokine release profiles, and changes in cell-surface markers.
• The team frames the platform as a human-relevant alternative to animal models, aligning with NIH initiatives to expand organ-on-chip approaches.
• Planned applications include comparing multiple classes of embolic agents and investigating embolization-driven changes such as hypoxia, immune infiltration, and angiogenic signaling.