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Teddi Mellencamp Pauses Immunotherapy and Clings to 50-50 Survival Odds

Pausing treatment to recover from debilitating side effects with daily support from her father

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John Mellencamp performs during the Grammy Hall Of Fame Gala at The Beverly Hilton on May 16, 2025, in Beverly Hills, California.
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Overview

  • On a July 29 podcast episode, Mellencamp said doctors have given her roughly equal odds of surviving stage 4 melanoma and brain metastases, yet she remains convinced she will live.
  • She halted her immunotherapy this month after weeks of severe fatigue and cognitive struggles left her too weak to continue.
  • Recent scans show substantial tumor shrinkage from her combined radiation, surgery and immunotherapy treatments, leading physicians to approve a temporary break.
  • Her father, musician John Mellencamp, has arranged round-the-clock nursing care and checks in daily to oversee her recovery.
  • She and her estranged husband have paused their divorce proceedings and are living together to provide stability for her and their three children during her treatment