Tau Neutralizes HSV-1 in Human Neuron Cultures, Pointing to Antiviral Roots of Alzheimer’s Features

Overview

• Mass General Brigham scientists report that phosphorylated tau binds HSV‑1 capsids and neutralizes the virus in human-derived neuron cultures.
• HSV‑1 exposure in the same model induced tau hyperphosphorylation and tangle-like aggregates resembling Alzheimer’s pathology.
• Infected neurons released hyperphosphorylated tau that trapped virus, indicating a feedback mechanism that could limit spread between neurons.
• The study builds on earlier work suggesting amyloid beta has antimicrobial activity, reframing classic Alzheimer’s hallmarks as potential defense responses.
• The peer-reviewed results appear in Nature Neuroscience, with authors noting that implications for human disease require in vivo and clinical validation.