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Tatiana Schlossberg’s AML Linked to Rare Chromosome 3 Inversion as Experts Detail Risks and Options

Specialists describe the inversion as highly resistant to standard chemotherapy.

Overview

  • Schlossberg disclosed her diagnosis in a Nov. 22 New Yorker essay, writing that doctors estimate she may have less than a year to live.
  • Her illness was first flagged in May 2024 hours after childbirth, when testing showed a white blood cell count of about 131,000 per microliter.
  • Her treatment has included chemotherapy, two bone-marrow transplants at Memorial Sloan Kettering, and enrollment in CAR-T cell therapy trials.
  • Inversion 3 appears in roughly 1% to 1.5% of AML cases and is tied to misexpression of genes such as EVI1 and GATA2 that drive aggressive disease.
  • Oncologists report no approved therapy specifically targets this subtype, though clinical trials of immune-based and targeted approaches are actively enrolling high-risk AML patients.