Study Uncovers Epigenetic Basis for Persistent Weight Gain After Dieting

Research reveals that changes in fat cells contribute to the difficulty of maintaining weight loss, highlighting the role of cellular memory.

The study, conducted by researchers at ETH Zurich, was published in the journal Nature.
Epigenetic changes in fat cells may cause the body to 'remember' its highest weight, leading to the Jo-Jo effect.
These changes affect gene activity without altering the DNA sequence, impacting metabolism long after weight loss.
Evidence from both human and mouse studies supports the existence of this 'adipogenic memory'.
Experts recommend avoiding crash diets and focusing on sustainable lifestyle changes to manage weight effectively.