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4w ago

Study Ties Lower Omega-3–Linked Blood Lipids to Alzheimer’s in Women

Researchers say the sex-specific pattern should be tested in randomized trials to see if boosting omega intake can alter disease trajectory.

Close up of woman holding a plate with avocado and salmon toast.
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The research suggests women could protect against the form of dementia by increasing their omega-3 intake, found in fatty fish or taken as daily supplements
Women are advised to include omega-3 fatty acids in their diet to prevent Alzheimer's disease.

Overview

  • The peer-reviewed study from King’s College London and Queen Mary University London analyzed plasma from 841 participants using high-resolution lipidomics.
  • Women with Alzheimer’s showed reduced unsaturated, omega-containing lipids and higher saturated lipids versus healthy women, a pattern not observed in men.
  • Highly unsaturated lipids, including DHA/EPA-containing species, correlated with better cognitive scores and lower biomarkers of neuronal damage and inflammation.
  • Authors recommend ensuring adequate omega intake but emphasize the findings are observational and call for randomized clinical trials, more diverse cohorts, and mechanistic research.
  • Scientists and funders noted limitations such as largely European samples and incomplete data on lipid-altering medications, cautioning against treating supplements as proven protection.