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3w ago

Study Rules Out Mystery Brain Disease in New Brunswick, Citing Misdiagnoses

A peer-reviewed JAMA study finds no evidence of a novel illness, attributing cases to known conditions, while provincial investigations continue.

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Premier Susan Holt and Health Minister John Dornan both say their investigation into what is causing atypical neurological symptoms will continue despite the recent release of a study debunking the existence of a 'mystery disease.'
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Overview

  • A May 2025 JAMA study reassessed 25 suspected cases and concluded they were misdiagnosed with known conditions such as Alzheimer’s, Parkinson’s, and cancer.
  • The study also examined 11 autopsies, finding no evidence of a new disease and a probability of less than 0.001 for its existence.
  • Neurologist Alier Marrero, who initially identified the cases, disputes the study's methods and findings, citing lack of consultation and a small sample size.
  • New Brunswick’s chief medical officer, Dr. Yves Léger, confirmed the province’s independent investigation into 222 cases is ongoing, with a report expected by summer 2025.
  • Patient advocacy groups and some families remain skeptical, attributing symptoms to potential environmental contamination, a theory rejected by researchers.