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Study Reveals Sex-Based Genetic Differences in Heart's Natural Pacemaker

Ohio State University research uncovers distinct gene expression patterns in men and women, shedding light on heart rate differences and arrhythmia risks.

Overview

  • The sinoatrial node (SAN), the heart's natural pacemaker, operates on different gene blueprints in men and women, influencing heart rate and rhythm risks.
  • Women exhibit higher levels of TBX3 and HCN1 genes, which drive faster heartbeats and are linked to sinus tachycardia prevalence.
  • Men's SAN cells show increased activity in inflammation and collagen-related genes, contributing to a higher risk of arrhythmias like atrial fibrillation.
  • The study utilized donated human hearts through Lifeline of Ohio to analyze sex-specific patterns in pacing, metabolism, inflammation, and fibrotic remodeling.
  • Published in the journal Circulation: Arrhythmia and Electrophysiology, the findings aim to advance personalized treatments for heart rhythm disorders.