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2mo ago

Study Reveals Sex-Based Genetic Differences in Heart's Natural Pacemaker

Ohio State University research uncovers distinct gene expression patterns in men and women, shedding light on heart rate differences and arrhythmia risks.

Why do women have faster heartbeats while men are more susceptible to developing irregular rhythms?
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Overview

  • The sinoatrial node (SAN), the heart's natural pacemaker, operates on different gene blueprints in men and women, influencing heart rate and rhythm risks.
  • Women exhibit higher levels of TBX3 and HCN1 genes, which drive faster heartbeats and are linked to sinus tachycardia prevalence.
  • Men's SAN cells show increased activity in inflammation and collagen-related genes, contributing to a higher risk of arrhythmias like atrial fibrillation.
  • The study utilized donated human hearts through Lifeline of Ohio to analyze sex-specific patterns in pacing, metabolism, inflammation, and fibrotic remodeling.
  • Published in the journal Circulation: Arrhythmia and Electrophysiology, the findings aim to advance personalized treatments for heart rhythm disorders.