Study Reveals Dual Role of Scratching in Skin Inflammation and Immune Defense

Researchers find that scratching worsens inflammation but helps reduce bacterial infections, offering insights into potential treatments for skin conditions.

A University of Pittsburgh study highlights the dual effects of scratching, showing it exacerbates skin inflammation while also aiding in bacterial defense.
Scratching triggers the release of substance P, activating mast cells that drive inflammation and intensify the itch-scratch cycle.
The research demonstrated that scratching reduced levels of Staphylococcus aureus, a common skin bacterium, suggesting an evolutionary benefit in certain contexts.
Findings suggest scratching's role as an evolutionary adaptation, balancing harmful inflammation with protective immune responses.
The study opens pathways for developing new treatments targeting mast cell receptors to manage chronic inflammatory skin conditions like dermatitis.

Australian Broadcasting Corporation