Study Reveals Cellular RNA's Key Role in Antiviral Immune Response

Researchers uncover how cellular RNA interacts with MAVS proteins to regulate immune signaling and combat RNA viruses.

Scientists from the University of Washington and Duke University have identified how cellular RNA regulates antiviral signaling through interactions with MAVS proteins.
The study highlights that cellular RNA contributes to the activation of MAVS signalosomes, which are critical in triggering interferons and other antiviral defenses.
Researchers demonstrated that MAVS proteins directly bind to host RNA, with these interactions enhancing the modulation of immune responses to maximize the antiviral effect.
The findings emphasize the importance of balancing antiviral responses to avoid potential tissue damage or autoimmune diseases, such as lupus, linked to overactive interferon pathways.
The study opens the door to potential RNA-based therapeutics targeting infections and autoimmune conditions by leveraging RNA's regulatory role in immune signaling.