Overview

• Researchers sequenced her genome and profiled her epigenome, transcriptome, proteome, metabolites and gut microbiome, publishing the single-subject analysis in Cell Reports Medicine.
• Her DNA carried variants linked to cardioprotection, preserved cognition and longer lifespan, and lacked risk variants commonly associated with cancer, Alzheimer’s disease and metabolic disorders.
• Blood and epigenetic readouts pointed to low inflammation, an excellent lipid profile with favorable HDL and LDL levels, and a biological age younger than her years despite very short telomeres.
• Her gut community was enriched in Bifidobacterium, a youthful pattern the team associated with frequent yogurt intake and a Mediterranean-style diet alongside lifelong habits that excluded smoking and alcohol.
• The authors describe the findings as hypothesis-generating, note they did not test exercise or drug effects, and urge validation in larger, diverse cohorts before drawing broad conclusions.