Overview

• The integrated genome-to-microbiome analysis was published in Cell Reports Medicine by a multi-institutional team led by Manel Esteller.
• Epigenetic clocks placed her biological age about 23 years below her chronological age, aligning with low inflammation, efficient autophagy and an exceptional lipid profile.
• Immune profiling showed T-cell populations typical of much younger people with preserved pathogen recognition and limited autoimmunity.
• Despite these strengths, the study documented extraordinarily short telomeres and evidence of clonal hematopoiesis consistent with advanced cellular aging.
• Authors report numerous rare variants linked to longevity and mitochondrial efficiency, a gut flora enriched in Bifidobacterium possibly supported by daily yogurt intake, and they caution that this single-case result needs broader validation.