Overview

• The team led by Dr. Manel Esteller at the Josep Carreras Institute published a multi‑omic analysis in Cell Reports Medicine using blood, saliva, urine and feces collected before Branyas’s 2024 death and compared her data with hundreds to thousands of external samples.
• Epigenetic measures indicated a biological age about 23 years younger by one clock, with other analyses suggesting a gap of roughly 10 to 15 years.
• Investigators reported exceptionally low systemic inflammation, efficient lipid metabolism and an immune system showing strong memory without signs of harmful auto‑inflammation.
• Her gut microbiome resembled that of much younger people and retained Bifidobacterium typically lost with age, which researchers noted could relate to her routine consumption of yogurt.
• Researchers identified rare gene variants associated with protection from cardiovascular disease, cancer and Alzheimer’s, observed unusually short telomeres and proposed a cancer‑limiting telomere hypothesis, while emphasizing that findings from a single case require replication.