Overview

• An integrated genome-to-microbiome analysis of blood, saliva, urine and feces found her epigenetic age was about 23 years younger than her chronological age.
• Her profiles showed very low systemic inflammation and highly efficient lipid handling, with high HDL and low VLDL and triglycerides.
• The gut microbiome resembled that of much younger people, with abundant Bifidobacterium, and the authors note she consumed yogurt daily.
• Telomeres were exceptionally short, and investigators hypothesize this may have curtailed malignant cell proliferation despite advanced age.
• Researchers identified rare protective genetic variants and propose the signals as hypothesis‑generating for future therapies, while outside experts stress the results cannot be generalized from a single case.