Overview
- Researchers at NeuRA, UNSW and the University of Sydney analyzed post-mortem human brain tissue and found spatially distinct alterations in the cerebrovasculature linked to Parkinson’s progression.
- The study reports an increased presence of non-functional “string vessels,” indicating microvascular loss in affected brain regions.
- Investigators also observed changes in cerebral blood flow dynamics and blood–brain barrier function associated with the disease.
- The work was posted on bioRxiv and is slated for publication in the journal Brain, according to the team.
- Follow-up analyses are underway to assess whether similar cerebrovascular changes occur in Alzheimer’s disease and dementia with Lewy bodies.